Neurosurgical Monitoring

M.Barth, H.-H.Capelle, E.Munich, C.Thome, F.Fielder, P.Schmiedek, P.Vajkoczy, "Effects of the selective endothelin A (ETa) receptor antagonist Clazosentan on cerebral perfusion and cerebral oxygenation following severe subarachnoid hemorrhage - preliminary results from a randomized clinical series", Acta Neurochirurgica, Aug. 2007. (download)

J.Jaeger, M.Soehle, MU.Schuhmann, D.Winkler, J.Meixensberger, "Correlation of continuously monitored regional cerebral blood flow and brain tissue oxygen", Acta Neurochirurgica, Jan. 2005. (link)

P. Horn, P. Vajkoczy, C. Thomé, E. Muench, L. Schilling, P. Schmiedek, "Xenon-induced flow activation in patients with cerebral insult who undergo xenon-enhanced ct blood flow studies", AJNR Am J Neuroradiol 2001 Sep;22(8):1543-9. 

C. Thomé, P. Vajkoczy, P. Horn, C. Bauhuf, U. Hübner, P.  Schmiedek, “Continuous monitoring of regional cerebral blood flow during temporary arterial occlusion in aneurysm surgery”, Journal of Neurosurgery, 95(3):402-411, September 2001.

J.C. Hemphill, M.M. Knudson, N. Derugin, D. Morabito, G. Manley, "Carbon dioxide reactivity and pressure Autoregulation of brain tissue oxygen", Neurosurgery, 48(2):377-384, February, 2001. 

P. Vajkoczy, P. Horn, C. Bauhuf, E. Munch, U. Hubner, D. Ing, C. Thome, C. Poeckler-Schoeninger, H. Roth, P. Schmiedek, "Effect of Intra-Arterial Papaverine on Regional Cerebral Blood Flow in Hemodynamically Relevant Cerebral Vasospasm", Stroke, 32:498-505, 2001. 

K. Geletneky, B. Hashemi, R. Ahmadi, A. Mehrabi, T. Steiner, H.H. Steiner, "Correlation of continuously measured regional cerebral blood flow and tissue partial oxygen pressure during periods of increasing intracranial pressure", Journal of Neurosurgical Anesthesiology, 12(4), 2000. 

P. Horn, P. Vajkoczy, C. Thomé, M. Quintel, H. Roth, L. Schilling, P. Schmiedek, "Effects of 30% Stable Xenon on Regional Cerebral Blood Flow in Patients with Intracranial Pathology", Keio Journal of Medicine, 49(1): A161-163, February 2000. 

P. Vajkoczy, U. Hubner, P. Horn, C. Bauhuf, C. Thome, L. Schilling, P. Schmiedek, "Intrathecal Sodium Nitroprusside Improves Cerebral Blood Flow and Oxygenation in Refractory Cerebral Vasospasm and Ischemia in Humans", Letter to the Editor, Stoke, 31:1194-b, 2000. 

P. Vajkoczy, H. Roth, P. Horn, T. Luecke, C. Thomé, U. Huebner, G.T. Martin, C. Zappletal, E. Klar, L. Schilling, P. Schmiedek, "Continuous monitoring of regional cerebral blood flow - experimental and clinical validation of a novel thermal diffusion microprobe", Journal of Neurosurgery, 93:265-274, August 2000. 

Organ Transplantation & Reconstructive Surgery

MB.Khot, PK.Maitz, BR.Phillips, HF.Bowman, JJ.Pribaz, DP.Orgill, "Thermal diffusion probe analysis of perfusion changes in vascular occlusions of rabbit pedicle flaps", Plastic & Reconstructive Surgery, Apr. 2005. (link)

T. Kraus, A. Mehrabi, M. Angelescu, M. Golling, J.R. Allenberg, E. Klar, “Characterization of renal parenchymal perfusion during experimental infrarenal aortic clamping and declamping with enhanced thermodiffusion electrodes”, Annals of Vascular Surgery 2001 Jul;15(4):447-56.

T. Kraus, A. Mehrabi, M. Golling, F. Schäffer, O. Bud, M.M. Gebhard, C. Herfarth, E. Klar, "Effects of exogenous endothelin-1 application on liver perfusion in native and transplanted porcine livers", Journal of Surgical Research, 93:272-281, 2000. 

R. Ricciardi, D.P. Foley, S.H. Quarfordt, J.M. Lewis, S.E. Donohue, S.M. Wheeler, G.T. Martin, W.C. Meyers, "Cold Ischemia Affects Regional Hepatic Tissue Perfusion", Hepatology, 30(4):253, Part 2 Supplement S, October, 1999. 

J. Scharf, C. Zapletal, T. Hess, U. Hoffmann, A. Mehrabi, D. Mihm, V. Hoffmann, G. Brix, T. Kraus, G.M. Richter, E. Klar, "Assessment of hepatic perfusion in pigs by pharmacokinetic analysis of dynamic MR images", Journal of Magnetic Resonance Imaging, 9(4): 568-572, 1999. 

G. Weiss, M. Golling, A. Mehrabi, C. Zapletal, F. Schaffer, C. Jahnke, H. Nentwich, M. von Frankenberg, O. Bud, T. Kraus, M.M. Gebhard, C. Herfarth, E. Klar "Cut-off value in thermodiffusion-assisted intrahepatic flow measurements after experimental liver transplantation", Transplantation Proceedings, 31(8):3247-3249, 1999. 

C. Zapletal, A. Mehrabi, J. Scharf, T. Hess, D. Mihm, C. Jahnke, F. Schaffer, M. Golling, T. Kraus, M.M. Gebhard, C. Herfarth, E. Klar, "Experimental evaluation of dynamic MRI for quantification of liver Perfusion", Transplantation Proceedings, 31(1-2): 421-422, 1999

E. Klar, M. Angelescu, C. Zapletal, T. Kraus, C. Herfarth, "Impairment of Hepatic Microcirculation as an Early Manifestation of Acute Rejection After Clinical Liver Transplantation" Transplantation Proceedings, 31(1-2):385-387, 1999. 

E. Klar, T. Kraus, J. Bleyl, W.H. Newman, H.F. Bowman, W. Hofmann, R. von Kummer, M. Bredt, C. Herfarth, "Thermodiffusion for continuous quantification of hepatic microcirculation - Validation and Potentials in Liver Transplantation", Microvascular Research, 58:156-166, 1999.

E. Klar, M. Angelescu, C. Zapletal, T. Kraus, M. Bredt, C. Herfarth, "Definition of Maximum Cold Ischemia Time Without Reduction of Graft Quality in Clinical Liver Transplantation", Transplantation Proceedings, 30:3683-3685, 1998.

T. Kraus, A. Mehrabi, M. Bredt, T. Schonfuss, M. Golling, M.M. Gebhard, C. Herfarth, E. Klar, "Characterization of Hepatic Microcirculatory Impairment Induced during Portal-Venous Infusion of Endothelin-1 by Thermal Diffusion Technology", Transplantation Proceedings, 30:3743-3745, 1998.

S-M. Maksan, T. Kraus, W.J. Hofmann, A. Mehrabi, M.M. Gebhard, C. Herfarth, E. Klar, "Hepatocellular Injury Early After Reperfusion is Correlated with Liver Microcirculation and Predicts Outcome After Transplantation", Transplantation Proceedings, 30:3716-3717, 1998. 

A. Mehrabi, T. Kraus, G. Otto, M. Golling, M.M. Gebhard, C. Herfarth, E. Klar, "Quantification of Hepatic Microcirculation and Intrahepatic Shunt Perfusion during Experimental Liver Transplantation", Transplantation Proceedings, 30:794-796, 1998. 

M. Angelescu, M. Bredt, T. Kraus, C. Weber, M. Wiesel, E. Klar, "Perioperative Monitoring of the Cortical Microcirculation in Clinical Renal Transplantation by Thermodiffusion", Transplantation Proceedings, 29:2790-2792, 1997. 

E. Klar, M. Bredt. T. Kraus, M. Angelescu, A. Mehrabi, N. Senninger, G. Otto, C. Herfarth, "Early Assessment of Reperfusion Injury by Intraoperative Quantification of Hepatic Microcirculation in Patients", Transplantation Proceedings, 29:362-363, 1997.

E. Klar, T. Kraus, B. Osswald, A. Mehrabi, J. Bleyl, C. Herfarth, G. Otto, "Necessity of a Recovery Phase After In Situ Liver Preparation to Improve Hepatic Microcirculation Prior to Organ Preservation", Transplantation Proceedings, 28(3):1867-1868, 1996. 

T. Kraus, E. Klar, B.R. Osswald, L. Fernandes, A. Mehrabi, M.M. Gebhard, C. Herfarth, "Continuous Measurement of Porcine Renal Cortex Microcirculation with Enhanced Thermal Diffusion Technology", Journal of Surgical Research, 61:531-536, 1996. 

E. Klar, T. Kraus, M. Bredt, B. Osswald, N. Senninger, C. Herfarth, G. Otto, "First clinical realization of continuous monitoring of liver microcirculation after transplantation by thermodiffusion", Transplantation International, 9:S140-S143, 1996. 

E. Klar, T. Kraus, J. Bleyl, W. Newman, F. Bowman, R. von Kummer, G. Otto, C. Herfarth, "Thermodiffusion as a Novel Method for Continuous Monitoring of the Hepatic Microcirculation after Liver Transplantation", Transplantation Proceedings, 27(5):2610-2612, 1995. 

Oncology

H. F. Bowman, W. H. Newman, M. G. Curley, S. C. Summit, S. Kumar, G. T. Martin, J. Hansen, G. K. Svensson, "Tumor Hyperthermia: Dense Thermometry, Dosimetry and Effects of Perfusion", Advances in Biological Heat and Mass Transfer, ASME, BED-Vol 18:23-32, December 1991. 

Methodology

G.T. Martin, H.F. Bowman, "Validation of real-time continuous perfusion measurement", Medical & Biological Engineering & Computing, 38(3):319-326, 2000. 

W.H. Newman, H.F. Bowman, D.P. Orgill, E. Klar, "A Methodology for in vivo Measurement of Blood Flow in Small Tissue Volumes", Advances in Heat and Mass Transfer in Biotechnology, HTD-Vol 322/BED-Vol 32, 99-105, 1995. 

W.H. Newman, S.C. Summit, T.A. Balasubramaniam, H.F. Bowman, "In-vitro and in vivo measurements of low level tissue flow", In Collected Papers in Heat Transfer, 41:51-56. ASME, 1988. 

H.F. Bowman, "Estimation of tissue blood flow", Chapter in Heat Transfer in Medicine and Biology: Analysis and Application, Vol. I, ed. by A. Shitzer, R. Eberhart, Plenum Press, New York, NY, pp. 193-230, 1985. 

J.W. Valvano, J.T. Allen, H.F. Bowman, "The simultaneous measurement of thermal conductivity, thermal diffusivity and perfusion in small volumes of tissue", Journal of Biomechanical Engineering, 106(3):192-197, 1984. 

J.W. Valvano, J.T. Allen, J.T. Walsh, D.J. Hnatowich, J.F. Tomera, H. Brunengraber, H.F. Bowman, "An isolated rat liver model system for the evaluation of thermal techniques to quantify perfusion", Journal of Biomechanical Engineering, 106(3):187-191, 1984

H.F. Bowman, "Heat transfer and thermal dosimetry", Journal of Microwave Power,16(2):122-133, 1981. 

H.F. Bowman, "The bio-heat transfer equation and discrimination of thermally significant vessels", Annals of the New York Academy of Sciences, 335:155-160, 1980. 

H.F. Bowman, T.A. Balasubramaniam, "A new technique utilizing thermistor probes for the measurement of thermal properties of biomaterials", Cryobiology, 13:572-580, 1976.

T.A. Balasubramaniam, H.F. Bowman, "Thermal conductivity and thermal diffusivity of biomaterials: A simultaneous measurement technique", Journal of Biomechanical Engineering, 99-K(3):148-154, 1977. 

H.F. Bowman, E.G. Cravalho, M. Woods, "Theory, measurement and application of thermal properties of biomaterials" Review Chapter for Annual Review of Biophysics and Bioengineering, 4:43-80, 1975. 

T.A. Balasubramaniam, H.F. Bowman, "Temperature field due to a time dependent heat source of spherical geometry in an infinite medium", Journal of Heat Transfer, 296-299, , August 1974.